Cortisol is a hormone that is required for a variety of bodily activities. Its secretion from the adrenal glands is controlled by the hypothalamus and the pituitary gland, two brain areas. Corticotropin-releasing hormone, or CRH, is secreted by the hypothalamus, a small region in the brain, and it works on the pituitary gland, which is also in the brain. Adrenocorticotropic hormone, or ACTH, is released by the pituitary gland, which stimulates the adrenal gland to produce cortisol. The adrenal gland's cortisol regulates the production of CRH and ACTH by feeding it back to the hypothalamus and pituitary gland.
Increased Thirst and Urination
Cushing's illness might take a long time to manifest. Excessive thirst and urination are two of the earliest symptoms of this condition. You could notice that you're replenishing your pet's water bowl more frequently than usual. They can be requesting more time outside. In addition, you may notice that your well-behaved dog is having accidents in the house. Cushing's disease is more common in older dogs, and as a result, the symptoms might be confused with urinary tract infections or even senility. Furthermore, increasing thirst could be a symptom of kidney disease.
Increased Appetite and Weight Gain
A dog's appetite will be stimulated by higher cortisol levels. As a result, individuals may consume more and acquire weight as a result. Your dog may find it difficult to walk around, jump up on objects, or even walk up stairs as a result of his weight gain. Cortisone also relaxes a dog's abdominal ligaments and causes their liver to inflate, giving them a pot-bellied appearance. These Cushing's symptoms, like urinary incontinence, might be confused with other prevalent conditions in senior dogs, such as arthritis.
If you suspect your dog has Cushing's disease, have your veterinarian examine their abdomen to check if their liver is enlarged. The results of this simple hands-on assessment may prompt your doctor to order additional tests to confirm or rule out the start of Cushing's disease and give vetoryl for dogs.
Symmetrical Hair Loss
Cushing's disease can cause a dog's fur to fall out, yet the fur on his legs and head will usually remain intact. Cushing's-related hair loss, on the other hand, primarily affects a dog's belly. Hair loss caused by Cushing's disease is usually symmetrical, affecting both sides of the dog's body equally.
Panting
When a dog has exerted themselves, is stressed, or is hot, it is natural for them to pant. If your dog appears to be panting more than usual, and this occurs in conjunction with the other symptoms, it may be a sign of Cushing's disease.
Thin Skin that Bruises Easily
Gently pinch a fold of skin near your dog's flank on their abdomen. In contrast to the fluffiness of healthy skin, a dog with Cushing's disease may have skin that seems thin to the touch.
Recurrence of Infections
There can be more chances of eye and ear infection when a dog is suffering from Cushing’s disease. In case there's regular itching or redness, do not delay to get in touch with the vet.
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